Description
Zaleplon is a non-benzodiazepine sedative-hypnotic. It enhances the calming effects of GABA, a chemical messenger in the brain, helping reduce the time needed to fall asleep.
What it is used for
Zaleplon is used for short-term sleep-onset insomnia in adults. It has not been shown consistently to improve frequent night-time waking or increase total sleep duration. Persistent sleep problems require assessment of their underlying cause.
Side effects
Common effects include drowsiness, dizziness, light-headedness, tingling sensations and poor coordination. Memory problems and next-day impairment can also occur.
Stop taking zaleplon and contact a clinician immediately if sleepwalking, sleep-driving or other activities occur while not fully awake. These behaviours can cause serious injury or death, even after one dose. A previous episode with zaleplon, zolpidem or eszopiclone must be discussed before treatment.
Breathing difficulties or swelling of the tongue or throat require emergency help. This list is not exhaustive.
Avoid alcohol and other sleeping medicines. Opioids and other sedatives can increase sedation and breathing risks. Do not drive until fully alert.
Recommended dosage
Reference prescribing information recommends 10 mg immediately before bed for most adults. Older or debilitated adults and people with mild to moderate liver impairment generally require 5 mg. Severe liver impairment makes treatment unsuitable.
The reference maximum is 20 mg, only when specifically prescribed; do not increase the dose independently. Allow 7–8 hours for sleep and avoid taking immediately after a heavy meal. Follow the prescription and supplied leaflet. Insomnia persisting after 7–10 days needs review. Discuss stopping because withdrawal symptoms can occur.
Storage guidelines
Store in a cool, dark place. Keep out of children’s sight and reach and do not use after expiry.
