Description
Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor that improves blood flow to the penis during sexual stimulation. Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) that affects the nerve signalling involved in ejaculation.
What it is used for
Sildenafil is used for erectile dysfunction, while dapoxetine is used for diagnosed premature ejaculation in adult men. These separate indications do not establish the safety, effectiveness or authorisation of this fixed-dose combination.
Dapoxetine prescribing information advises against use with PDE5 inhibitors such as sildenafil because the combination can reduce the body’s ability to maintain blood pressure when standing.
Side effects
Recognised effects of the individual ingredients include headache, nausea, dizziness, flushing, indigestion, nasal congestion and visual disturbances. Fainting and a fall in blood pressure are important combination risks.
Seek urgent medical help for chest pain, collapse, seizures, sudden vision or hearing loss, severe allergic symptoms, or an erection lasting more than four hours. If chest pain occurs, do not take nitrates; tell the treating clinician what was taken and when. This list is not exhaustive.
Nitrates, recreational nitrites (“poppers”), riociguat, antidepressants, tramadol and other serotonergic medicines can cause serious interactions. Avoid alcohol. Heart disease, previous fainting and liver problems require assessment.
Recommended dosage
A single pill is considered to be a single dose, never take more than the recommended daily amount. Obtain a prescriber’s assessment before use.
Storage guidelines
Store in a cool, dark place. Keep out of children’s sight and reach and do not use after expiry.
